Define Negative Correlation

1) Advantages of combination antacids :-

Combination antacids are a type of medication that contains a mixture of different antacid compounds, such as calcium carbonate, magnesium hydroxide, and aluminum hydroxide. Here are some advantages of combination antacids:

1. Rapid Relief: Combination antacids work quickly to relieve symptoms of acid reflux, heartburn, and indigestion. They neutralize stomach acid and provide rapid relief from discomfort and pain.

2. Enhanced Efficacy: By combining different types of antacids, combination antacids can provide enhanced efficacy compared to individual antacid compounds. For example, calcium carbonate may provide quick relief, while magnesium hydroxide may have a longer duration of action.

3. Balanced pH: The different antacid compounds in combination antacids can help balance the pH in the stomach, reducing the risk of rebound acid production.

4. Convenience: Combination antacids can be more convenient than taking multiple individual antacid compounds. They are available in a variety of forms, such as tablets, liquids, and chewable tablets, making them easy to take on the go.

5. Cost-effective: Combination antacids can be more cost-effective than individual antacid compounds, as they provide multiple active ingredients in a single medication.

2) Mechanism of antimicrobials :-

Antimicrobials are compounds that are used to inhibit or kill microorganisms such as bacteria, fungi, and viruses. The mechanism of action of antimicrobials can vary depending on the type of microbe they are targeting and the specific compound being used.

Here are some general mechanisms of antimicrobials:-

1. Inhibition of cell wall synthesis: Many bacteria have a cell wall that provides structural support and protection. Antimicrobial compounds can target this cell wall synthesis, preventing bacteria from forming or repairing their cell wall, leading to cell death.

2. Inhibition of protein synthesis: Bacteria, fungi, and viruses all require protein synthesis to function and replicate. Antimicrobial compounds can target specific components of the protein synthesis process, preventing the microbe from making the proteins it needs to survive.

3. Inhibition of nucleic acid synthesis: Antimicrobial compounds can also target the synthesis of nucleic acids such as DNA and RNA. Without these essential molecules, microorganisms cannot replicate or function correctly, leading to cell death.

4. Disruption of cell membranes: Cell membranes are essential for the survival of many types of microorganisms. Antimicrobial compounds can disrupt the integrity of these membranes, leading to the loss of essential nutrients and ions and ultimately, cell death.

5. Inhibition of enzyme activity: Many enzymes are essential for the survival of microorganisms. Antimicrobial compounds can target specific enzymes, inhibiting their activity and leading to the death of the microbe.